Cat: HF-4001
Annexin V/ANXA5, Human, HEK293 Cells,Tag Free: Product Information
> 95%, determined by SDS-PAGE
<0.010 EU per 1 ug of the protein by the LAL method.
Testing in progress
P08758
Human embryonic kidney cell, HEK293-derived human Annexin V protein
Ala2-Asp320
35.8 kDa
Solution protein
Dissolved in sterile PBS buffer to a concentration of 1.0 mg/mL.
This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Avoid repeated freeze-thaw cycles.
It is recommended that the protein be aliquoted for optimal storage.
12 months from date of receipt, -20 to -70 °C as supplied.
Shipping with dry ice.
Annexin V/ANXA5, Human, HEK293 Cells,Tag Free: Product Information
4 ug/lane protein wasresolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by CoomassieBlue staining.
Size-exclusion chromatography of recombinant human Annexin V protein (280 nm absorbance)
Annexin V/ANXA5, Human, HEK293 Cells,Tag Free: Product Information
Human ANX5 Protein; ENX2 Protein; HEL-S-7 Protein; PP4 Protein; RPRGL3 Protein
Annexin V/ANXA5, Human, HEK293 Cells,Tag Free: Product Information
The placental anticoagulant protein Annexin A5 (ANXA5) is a multifunctional protein that is highly expressed on the apical surfaces of syncytiotrophoblasts, and plays an important role in haemostatic regulations, maintaining blood fluidity of the placenta. Annexin V is a member of a calcium and phospholipid binding family of proteins with vascular anticoagulant activity. It is also known as PP4, PAP I, CPB-I, CaBP33, VACa, anchorin CII, lipocortin-V, endonexin II, and thromboplastin inhibitor. ANXA5 could be used as a biomarker for the early detection of PE and for the prediction of its severity. ANXA5 as an embryonic anticoagulant that appears deficient in contiguous specter of thrombophilia-related pregnancy complications culminating more frequently in miscarriage in a maternal M2 carrier background. As a potential indicator for malignancy and lymphatic metastasis, ANXA5 overexpression increases in vitro migration and invasion of Hca-P cell, promotes in vivo malignancy, LNM rate and level of Hca-P-transplanted mice. Hereditary thrombophilias can impair vascular placental functions and predispose to the birth of small-forgestational age (SGA) babies. The placental anticoagulant protein annexin A5 (ANXA5) may contribute to this process. A functional haplotype (M2) within the ANXA5 gene is associated with fetal loss and venous thrombosis.
1. Cederholm A, et al. (2007) Ann N Y Acad Sci. 1108: 96-103.
2. Schlaepfer DD, et al. (1992) Biochemistry. 31: 1886-91.
3. Vermes I, et al. (1995) J Immunol Methods. 184 (1): 39-51.
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